The 2021–22 OFI Crete F.C. season was the club's 97th season in existence and the fourth consecutive season in the top flight of Greek football. In addition to the domestic league, OFI participated in this season's edition of the Greek Football Cup. The season covered the period from 1 July 2021 to 30 June 2022.
Source: Superleague Greece Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Play-offs (neutral ground). (Note: Criteria 6 is only used if needed to decide champion, teams for relegation or teams for UEFA competitions).
Source: Super League Greece, Soccerway Rules for classification: 1) Points; 2) Head-to-head points (Regular season and play-out); 3) Head-to-head goal difference (Regular season and play-out); 4) Regular season position.[1]